Impact of a cis-associated gene expression SNP in 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance
Identifieur interne : 002C63 ( Main/Exploration ); précédent : 002C62; suivant : 002C64Impact of a cis-associated gene expression SNP in 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance
Auteurs : Ming Li [République populaire de Chine, États-Unis] ; Xiong-Jian Luo [République populaire de Chine, États-Unis] ; Mikael Landén [Suède] ; Sarah E. Bergen [Suède, États-Unis] ; Christina M. Hultman [Suède] ; Xiao Li [République populaire de Chine] ; Wen Zhang [République populaire de Chine] ; Yong-Gang Yao [République populaire de Chine] ; Chen Zhang [République populaire de Chine] ; Jiewei Liu [République populaire de Chine] ; Manuel Mattheisen [Danemark] ; Sven Cichon [Suisse, Allemagne] ; Thomas W. Mühleisen [Allemagne] ; Franziska A. Degenhardt [Allemagne] ; Markus M. Nöthen [Allemagne] ; Thomas G. Schulze [Allemagne] ; Maria Grigoroiu-Serbanescu [Roumanie] ; Hao Li [États-Unis] ; Chris K. Fuller [États-Unis] ; Chunhui Chen [République populaire de Chine] ; Qi Dong [République populaire de Chine] ; Chuansheng Chen [États-Unis] ; Stéphane Jamain [France] ; Marion Leboyer [France] ; Frank Bellivier [France] ; Bruno Etain [France] ; Jean-Pierre Kahn [France] ; Chantal Henry [France] ; Martin Preisig [Suisse] ; Zoltán Kutalik [Suisse] ; Enrique Castelao [Suisse] ; Adam Wright [Australie] ; Philip B. Mitchell [Australie] ; Janice M. Fullerton [Australie] ; Peter R. Schofield [Australie] ; Grant W. Montgomery [Australie] ; Sarah E. Medland [Australie] ; Scott D. Gordon [Australie] ; Nicholas G. Martin [Australie] ; Marcella Rietschel [Allemagne] ; Chunyu Liu [États-Unis] ; Joel E. Kleinman [États-Unis] ; Thomas M. Hyde [États-Unis] ; Daniel R. Weinberger [États-Unis] ; Bing Su [République populaire de Chine]Source :
- The British journal of psychiatry : the journal of mental science [ 0007-1250 ] ; 2015.
Abstract
Bipolar disorder (BPD) is a highly heritable polygenic disorder. Recent enrichment analyses suggest that there may be true risk variants for BPD among the expression quantitative trait loci (eQTL) in the brain.
We sought to assess the impact of eQTL variants on BPD risk by combining data from both BPD genome-wide association study (GWAS) and brain eQTL.
To detect single-nucleotide polymorphisms (SNPs) that influence expression levels of genes associated with BPD, we jointly analyzed data from a BPD GWAS (7,481 cases and 9,250 controls) and a genome-wide brain (cortical) eQTL (193 healthy controls) using a Bayesian statistical method, with independent follow-up replications. The identified risk SNP was then further tested for association with hippocampal volume (N=5,775) and cognitive performance (N=342) among healthy subjects.
Integrative analysis revealed a significant association between a brain eQTL rs6088662 in 20q11.22 and BPD (Log Bayes Factor=5.48; BPD p-val=5.85×10−5). Follow-up studies across multiple independent samples confirmed the association of the risk SNP (rs6088662) with gene expression and BPD susceptibility (p-val=3.54×10−8). Further exploratory analysis revealed that rs6088662 is also associated with hippocampal volume and cognitive performance in healthy subjects.
Our findings suggest that 20q11.22 is likely a risk region for BPD, highlighting the informativeness of integrating functional annotation of genetic variants for gene expression in advancing our understanding of the biological basis underlying complex diseases such as BPD.
Url:
DOI: 10.1192/bjp.bp.114.156976
PubMed: 26338991
PubMed Central: 4829352
Affiliations:
- Allemagne, Australie, Danemark, France, Roumanie, République populaire de Chine, Suisse, Suède, États-Unis
- Bade-Wurtemberg, Basse-Saxe, Californie, Canton de Vaud, District de Cologne, District de Karlsruhe, Grand Est, Illinois, Lorraine (région), Maryland, Massachusetts, Nouvelle-Galles du Sud, Rhénanie-du-Nord-Westphalie, Svealand, État de New York, Île-de-France
- Bonn, Chicago, Créteil, Göttingen, Lausanne, Mannheim, Paris, Pékin, Stockholm, Sydney, Toul
- Université de l'Illinois à Chicago
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id="A9">Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Jiewei" sort="Liu, Jiewei" uniqKey="Liu J" first="Jiewei" last="Liu">Jiewei Liu</name><affiliation wicri:level="1"><nlm:aff id="A1">State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 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Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name><affiliation wicri:level="1"><nlm:aff id="A11">Division of Medical Genetics, University of Basel, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Division of Medical Genetics, University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A12">Institute of Human Genetics and Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics and Department of Genomics, Life and Brain Center, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Brain, Genomic Imaging, Research Centre Jülich, D-52425 Jülich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Brain, Genomic Imaging, Research Centre Jülich, D-52425 Jülich</wicri:regionArea><wicri:noRegion>52425 Jülich</wicri:noRegion><wicri:noRegion>52425 Jülich</wicri:noRegion><wicri:noRegion>D-52425 Jülich</wicri:noRegion></affiliation></author><author><name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name><affiliation wicri:level="3"><nlm:aff id="A12">Institute of Human Genetics and Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics and Department of Genomics, Life and Brain Center, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Brain, Genomic Imaging, Research Centre Jülich, D-52425 Jülich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Brain, Genomic Imaging, Research Centre Jülich, D-52425 Jülich</wicri:regionArea><wicri:noRegion>52425 Jülich</wicri:noRegion><wicri:noRegion>52425 Jülich</wicri:noRegion><wicri:noRegion>D-52425 Jülich</wicri:noRegion></affiliation></author><author><name sortKey="Degenhardt, Franziska A" sort="Degenhardt, Franziska A" uniqKey="Degenhardt F" first="Franziska A." last="Degenhardt">Franziska A. Degenhardt</name><affiliation wicri:level="3"><nlm:aff id="A12">Institute of Human Genetics and Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics and Department of Genomics, Life and Brain Center, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name><affiliation wicri:level="3"><nlm:aff id="A12">Institute of Human Genetics and Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics and Department of Genomics, Life and Brain Center, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Schulze, Thomas G" sort="Schulze, Thomas G" uniqKey="Schulze T" first="Thomas G." last="Schulze">Thomas G. Schulze</name><affiliation wicri:level="3"><nlm:aff id="A15">Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A16">Section on Psychiatric Genetics, Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August-University, Göttingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section on Psychiatric Genetics, Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August-University, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Grigoroiu Serbanescu, Maria" sort="Grigoroiu Serbanescu, Maria" uniqKey="Grigoroiu Serbanescu M" first="Maria" last="Grigoroiu-Serbanescu">Maria Grigoroiu-Serbanescu</name><affiliation wicri:level="1"><nlm:aff id="A17">Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania</nlm:aff><country xml:lang="fr">Roumanie</country><wicri:regionArea>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest</wicri:regionArea><wicri:noRegion>Bucharest</wicri:noRegion></affiliation></author><author><name sortKey="Li, Hao" sort="Li, Hao" uniqKey="Li H" first="Hao" last="Li">Hao Li</name><affiliation wicri:level="2"><nlm:aff id="A18">Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Fuller, Chris K" sort="Fuller, Chris K" uniqKey="Fuller C" first="Chris K." last="Fuller">Chris K. Fuller</name><affiliation wicri:level="2"><nlm:aff id="A18">Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Chen, Chunhui" sort="Chen, Chunhui" uniqKey="Chen C" first="Chunhui" last="Chen">Chunhui Chen</name><affiliation wicri:level="3"><nlm:aff id="A19">State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A20">Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Dong, Qi" sort="Dong, Qi" uniqKey="Dong Q" first="Qi" last="Dong">Qi Dong</name><affiliation wicri:level="3"><nlm:aff id="A19">State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A20">Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Chen, Chuansheng" sort="Chen, Chuansheng" uniqKey="Chen C" first="Chuansheng" last="Chen">Chuansheng Chen</name><affiliation wicri:level="2"><nlm:aff id="A21">Department of Psychology and Social Behavior, University of California, Irvine, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology and Social Behavior, University of California, Irvine, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Jamain, Stephane" sort="Jamain, Stephane" uniqKey="Jamain S" first="Stéphane" last="Jamain">Stéphane Jamain</name><affiliation wicri:level="3"><nlm:aff id="A22">Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U 955, IMRB, Psychiatrie Génétique, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A23">Université Paris Est, Faculté de Médecine, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A24">Fondation Fondamental, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Fondamental, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name><affiliation wicri:level="3"><nlm:aff id="A22">Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U 955, IMRB, Psychiatrie Génétique, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A23">Université Paris Est, Faculté de Médecine, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A24">Fondation Fondamental, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Fondamental, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A25">AP-HP, Hôpital A. Chenevier - H. Mondor, Pôle de Psychiatrie, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital A. Chenevier - H. Mondor, Pôle de Psychiatrie, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Bellivier, Frank" sort="Bellivier, Frank" uniqKey="Bellivier F" first="Frank" last="Bellivier">Frank Bellivier</name><affiliation wicri:level="3"><nlm:aff id="A22">Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U 955, IMRB, Psychiatrie Génétique, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A24">Fondation Fondamental, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Fondamental, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A26">AP-HP, Groupe hospitalier Lariboisière - F. Widal, Pôle de Psychiatrie, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe hospitalier Lariboisière - F. Widal, Pôle de Psychiatrie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A27">Université Paris Diderot, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Etain, Bruno" sort="Etain, Bruno" uniqKey="Etain B" first="Bruno" last="Etain">Bruno Etain</name><affiliation wicri:level="3"><nlm:aff id="A22">Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U 955, IMRB, Psychiatrie Génétique, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A23">Université Paris Est, Faculté de Médecine, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A24">Fondation Fondamental, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Fondamental, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A25">AP-HP, Hôpital A. Chenevier - H. Mondor, Pôle de Psychiatrie, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital A. Chenevier - H. Mondor, Pôle de Psychiatrie, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Kahn, Jean Pierre" sort="Kahn, Jean Pierre" uniqKey="Kahn J" first="Jean-Pierre" last="Kahn">Jean-Pierre Kahn</name><affiliation wicri:level="3"><nlm:aff id="A24">Fondation Fondamental, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Fondamental, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A28">Département de Psychiatrie et de Psychologie Clinique, CHU de Nancy, Hôpital Jeanne d'Arc, Toul, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département de Psychiatrie et de Psychologie Clinique, CHU de Nancy, Hôpital Jeanne d'Arc, Toul</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Toul</settlement></placeName></affiliation></author><author><name sortKey="Henry, Chantal" sort="Henry, Chantal" uniqKey="Henry C" first="Chantal" last="Henry">Chantal Henry</name><affiliation wicri:level="3"><nlm:aff id="A22">Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U 955, IMRB, Psychiatrie Génétique, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A23">Université Paris Est, Faculté de Médecine, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A24">Fondation Fondamental, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Fondamental, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A25">AP-HP, Hôpital A. Chenevier - H. Mondor, Pôle de Psychiatrie, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital A. Chenevier - H. Mondor, Pôle de Psychiatrie, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Preisig, Martin" sort="Preisig, Martin" uniqKey="Preisig M" first="Martin" last="Preisig">Martin Preisig</name><affiliation wicri:level="1"><nlm:aff id="A29">Department of Psychiatry, Centre Hospitalier Universitaire Vaudois, Prilly, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Psychiatry, Centre Hospitalier Universitaire Vaudois, Prilly</wicri:regionArea><wicri:noRegion>Prilly</wicri:noRegion></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><affiliation wicri:level="3"><nlm:aff id="A30">Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A31">Swiss Institute of Bioinformatics, Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Bioinformatics, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Castelao, Enrique" sort="Castelao, Enrique" uniqKey="Castelao E" first="Enrique" last="Castelao">Enrique Castelao</name><affiliation wicri:level="1"><nlm:aff id="A29">Department of Psychiatry, Centre Hospitalier Universitaire Vaudois, Prilly, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Psychiatry, Centre Hospitalier Universitaire Vaudois, Prilly</wicri:regionArea><wicri:noRegion>Prilly</wicri:noRegion></affiliation></author><author><name sortKey="Wright, Adam" sort="Wright, Adam" uniqKey="Wright A" first="Adam" last="Wright">Adam Wright</name><affiliation wicri:level="1"><nlm:aff id="A32">School of Psychiatry, University of New South Wales, Randwick, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Psychiatry, University of New South Wales, Randwick</wicri:regionArea><wicri:noRegion>Randwick</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A33">Black Dog Institute, Prince of Wales Hospital, Randwick, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Black Dog Institute, Prince of Wales Hospital, Randwick</wicri:regionArea><wicri:noRegion>Randwick</wicri:noRegion></affiliation></author><author><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B." last="Mitchell">Philip B. Mitchell</name><affiliation wicri:level="1"><nlm:aff id="A32">School of Psychiatry, University of New South Wales, Randwick, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Psychiatry, University of New South Wales, Randwick</wicri:regionArea><wicri:noRegion>Randwick</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A33">Black Dog Institute, Prince of Wales Hospital, Randwick, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Black Dog Institute, Prince of Wales Hospital, Randwick</wicri:regionArea><wicri:noRegion>Randwick</wicri:noRegion></affiliation></author><author><name sortKey="Fullerton, Janice M" sort="Fullerton, Janice M" uniqKey="Fullerton J" first="Janice M." last="Fullerton">Janice M. Fullerton</name><affiliation wicri:level="3"><nlm:aff id="A34">Neuroscience Research Australia, Randwick, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Neuroscience Research Australia, Randwick, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A35">School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R." last="Schofield">Peter R. Schofield</name><affiliation wicri:level="3"><nlm:aff id="A34">Neuroscience Research Australia, Randwick, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Neuroscience Research Australia, Randwick, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A35">School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><nlm:aff id="A36">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name><affiliation wicri:level="1"><nlm:aff id="A36">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Gordon, Scott D" sort="Gordon, Scott D" uniqKey="Gordon S" first="Scott D." last="Gordon">Scott D. Gordon</name><affiliation wicri:level="1"><nlm:aff id="A36">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:aff id="A36">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name><affiliation wicri:level="3"><nlm:aff id="A15">Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Liu, Chunyu" sort="Liu, Chunyu" uniqKey="Liu C" first="Chunyu" last="Liu">Chunyu Liu</name><affiliation wicri:level="4"><nlm:aff id="A37">Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de l'Illinois à Chicago</orgName></affiliation></author><author><name sortKey="Kleinman, Joel E" sort="Kleinman, Joel E" uniqKey="Kleinman J" first="Joel E." last="Kleinman">Joel E. Kleinman</name><affiliation wicri:level="2"><nlm:aff id="A2">Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hyde, Thomas M" sort="Hyde, Thomas M" uniqKey="Hyde T" first="Thomas M." last="Hyde">Thomas M. Hyde</name><affiliation wicri:level="2"><nlm:aff id="A2">Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Weinberger, Daniel R" sort="Weinberger, Daniel R" uniqKey="Weinberger D" first="Daniel R." last="Weinberger">Daniel R. Weinberger</name><affiliation wicri:level="2"><nlm:aff id="A2">Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Su, Bing" sort="Su, Bing" uniqKey="Su B" first="Bing" last="Su">Bing Su</name><affiliation wicri:level="1"><nlm:aff id="A1">State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26338991</idno><idno type="pmc">4829352</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829352</idno><idno type="RBID">PMC:4829352</idno><idno type="doi">10.1192/bjp.bp.114.156976</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001C85</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C85</idno><idno type="wicri:Area/Pmc/Curation">001B43</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001B43</idno><idno type="wicri:Area/Pmc/Checkpoint">000F22</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000F22</idno><idno type="wicri:Area/Ncbi/Merge">002A19</idno><idno type="wicri:Area/Ncbi/Curation">002A19</idno><idno type="wicri:Area/Ncbi/Checkpoint">002A19</idno><idno type="wicri:doubleKey">0007-1250:2015:Li M:impact:of:a</idno><idno type="wicri:Area/Main/Merge">002C63</idno><idno type="wicri:Area/Main/Curation">002C63</idno><idno type="wicri:Area/Main/Exploration">002C63</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Impact of a <italic>cis</italic>-associated gene expression SNP in 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance</title><author><name sortKey="Li, Ming" sort="Li, Ming" uniqKey="Li M" first="Ming" last="Li">Ming Li</name><affiliation wicri:level="1"><nlm:aff id="A1">State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Luo, Xiong Jian" sort="Luo, Xiong Jian" uniqKey="Luo X" first="Xiong-Jian" last="Luo">Xiong-Jian Luo</name><affiliation wicri:level="1"><nlm:aff id="A3">Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">University of Rochester Flaum Eye Institute, University of Rochester, Rochester, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Rochester Flaum Eye Institute, University of Rochester, Rochester, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Landen, Mikael" sort="Landen, Mikael" uniqKey="Landen M" first="Mikael" last="Landén">Mikael Landén</name><affiliation wicri:level="3"><nlm:aff id="A5">Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Section of Psychiatry and Neurochemistry, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Section of Psychiatry and Neurochemistry, Sahlgrenska Academy at Gothenburg University, Gothenburg</wicri:regionArea><wicri:noRegion>Gothenburg</wicri:noRegion></affiliation></author><author><name sortKey="Bergen, Sarah E" sort="Bergen, Sarah E" uniqKey="Bergen S" first="Sarah E." last="Bergen">Sarah E. Bergen</name><affiliation wicri:level="3"><nlm:aff id="A5">Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A7">Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hultman, Christina M" sort="Hultman, Christina M" uniqKey="Hultman C" first="Christina M." last="Hultman">Christina M. Hultman</name><affiliation wicri:level="3"><nlm:aff id="A5">Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Li, Xiao" sort="Li, Xiao" uniqKey="Li X" first="Xiao" last="Li">Xiao Li</name><affiliation wicri:level="1"><nlm:aff id="A3">Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Wen" sort="Zhang, Wen" uniqKey="Zhang W" first="Wen" last="Zhang">Wen Zhang</name><affiliation wicri:level="1"><nlm:aff id="A3">Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Yao, Yong Gang" sort="Yao, Yong Gang" uniqKey="Yao Y" first="Yong-Gang" last="Yao">Yong-Gang Yao</name><affiliation wicri:level="1"><nlm:aff id="A3">Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Chen" sort="Zhang, Chen" uniqKey="Zhang C" first="Chen" last="Zhang">Chen Zhang</name><affiliation wicri:level="1"><nlm:aff id="A9">Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Jiewei" sort="Liu, Jiewei" uniqKey="Liu J" first="Jiewei" last="Liu">Jiewei Liu</name><affiliation wicri:level="1"><nlm:aff id="A1">State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Mattheisen, Manuel" sort="Mattheisen, Manuel" uniqKey="Mattheisen M" first="Manuel" last="Mattheisen">Manuel Mattheisen</name><affiliation wicri:level="1"><nlm:aff id="A10">Department of Biomedicine, Aarhus University, Aarhus C, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Biomedicine, Aarhus University, Aarhus C</wicri:regionArea><wicri:noRegion>Aarhus C</wicri:noRegion></affiliation></author><author><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name><affiliation wicri:level="1"><nlm:aff id="A11">Division of Medical Genetics, University of Basel, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Division of Medical Genetics, University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A12">Institute of Human Genetics and Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics and Department of Genomics, Life and Brain Center, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Brain, Genomic Imaging, Research Centre Jülich, D-52425 Jülich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Brain, Genomic Imaging, Research Centre Jülich, D-52425 Jülich</wicri:regionArea><wicri:noRegion>52425 Jülich</wicri:noRegion><wicri:noRegion>52425 Jülich</wicri:noRegion><wicri:noRegion>D-52425 Jülich</wicri:noRegion></affiliation></author><author><name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name><affiliation wicri:level="3"><nlm:aff id="A12">Institute of Human Genetics and Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics and Department of Genomics, Life and Brain Center, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Brain, Genomic Imaging, Research Centre Jülich, D-52425 Jülich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Brain, Genomic Imaging, Research Centre Jülich, D-52425 Jülich</wicri:regionArea><wicri:noRegion>52425 Jülich</wicri:noRegion><wicri:noRegion>52425 Jülich</wicri:noRegion><wicri:noRegion>D-52425 Jülich</wicri:noRegion></affiliation></author><author><name sortKey="Degenhardt, Franziska A" sort="Degenhardt, Franziska A" uniqKey="Degenhardt F" first="Franziska A." last="Degenhardt">Franziska A. Degenhardt</name><affiliation wicri:level="3"><nlm:aff id="A12">Institute of Human Genetics and Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics and Department of Genomics, Life and Brain Center, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name><affiliation wicri:level="3"><nlm:aff id="A12">Institute of Human Genetics and Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics and Department of Genomics, Life and Brain Center, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Schulze, Thomas G" sort="Schulze, Thomas G" uniqKey="Schulze T" first="Thomas G." last="Schulze">Thomas G. Schulze</name><affiliation wicri:level="3"><nlm:aff id="A15">Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A16">Section on Psychiatric Genetics, Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August-University, Göttingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section on Psychiatric Genetics, Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August-University, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Grigoroiu Serbanescu, Maria" sort="Grigoroiu Serbanescu, Maria" uniqKey="Grigoroiu Serbanescu M" first="Maria" last="Grigoroiu-Serbanescu">Maria Grigoroiu-Serbanescu</name><affiliation wicri:level="1"><nlm:aff id="A17">Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania</nlm:aff><country xml:lang="fr">Roumanie</country><wicri:regionArea>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest</wicri:regionArea><wicri:noRegion>Bucharest</wicri:noRegion></affiliation></author><author><name sortKey="Li, Hao" sort="Li, Hao" uniqKey="Li H" first="Hao" last="Li">Hao Li</name><affiliation wicri:level="2"><nlm:aff id="A18">Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Fuller, Chris K" sort="Fuller, Chris K" uniqKey="Fuller C" first="Chris K." last="Fuller">Chris K. Fuller</name><affiliation wicri:level="2"><nlm:aff id="A18">Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Chen, Chunhui" sort="Chen, Chunhui" uniqKey="Chen C" first="Chunhui" last="Chen">Chunhui Chen</name><affiliation wicri:level="3"><nlm:aff id="A19">State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A20">Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Dong, Qi" sort="Dong, Qi" uniqKey="Dong Q" first="Qi" last="Dong">Qi Dong</name><affiliation wicri:level="3"><nlm:aff id="A19">State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A20">Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Chen, Chuansheng" sort="Chen, Chuansheng" uniqKey="Chen C" first="Chuansheng" last="Chen">Chuansheng Chen</name><affiliation wicri:level="2"><nlm:aff id="A21">Department of Psychology and Social Behavior, University of California, Irvine, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology and Social Behavior, University of California, Irvine, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Jamain, Stephane" sort="Jamain, Stephane" uniqKey="Jamain S" first="Stéphane" last="Jamain">Stéphane Jamain</name><affiliation wicri:level="3"><nlm:aff id="A22">Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U 955, IMRB, Psychiatrie Génétique, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A23">Université Paris Est, Faculté de Médecine, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A24">Fondation Fondamental, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Fondamental, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name><affiliation wicri:level="3"><nlm:aff id="A22">Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U 955, IMRB, Psychiatrie Génétique, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A23">Université Paris Est, Faculté de Médecine, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A24">Fondation Fondamental, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Fondamental, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A25">AP-HP, Hôpital A. Chenevier - H. Mondor, Pôle de Psychiatrie, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital A. Chenevier - H. Mondor, Pôle de Psychiatrie, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Bellivier, Frank" sort="Bellivier, Frank" uniqKey="Bellivier F" first="Frank" last="Bellivier">Frank Bellivier</name><affiliation wicri:level="3"><nlm:aff id="A22">Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U 955, IMRB, Psychiatrie Génétique, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A24">Fondation Fondamental, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Fondamental, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A26">AP-HP, Groupe hospitalier Lariboisière - F. Widal, Pôle de Psychiatrie, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe hospitalier Lariboisière - F. Widal, Pôle de Psychiatrie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A27">Université Paris Diderot, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Etain, Bruno" sort="Etain, Bruno" uniqKey="Etain B" first="Bruno" last="Etain">Bruno Etain</name><affiliation wicri:level="3"><nlm:aff id="A22">Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U 955, IMRB, Psychiatrie Génétique, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A23">Université Paris Est, Faculté de Médecine, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A24">Fondation Fondamental, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Fondamental, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A25">AP-HP, Hôpital A. Chenevier - H. Mondor, Pôle de Psychiatrie, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital A. Chenevier - H. Mondor, Pôle de Psychiatrie, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Kahn, Jean Pierre" sort="Kahn, Jean Pierre" uniqKey="Kahn J" first="Jean-Pierre" last="Kahn">Jean-Pierre Kahn</name><affiliation wicri:level="3"><nlm:aff id="A24">Fondation Fondamental, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Fondamental, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A28">Département de Psychiatrie et de Psychologie Clinique, CHU de Nancy, Hôpital Jeanne d'Arc, Toul, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département de Psychiatrie et de Psychologie Clinique, CHU de Nancy, Hôpital Jeanne d'Arc, Toul</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Toul</settlement></placeName></affiliation></author><author><name sortKey="Henry, Chantal" sort="Henry, Chantal" uniqKey="Henry C" first="Chantal" last="Henry">Chantal Henry</name><affiliation wicri:level="3"><nlm:aff id="A22">Inserm U 955, IMRB, Psychiatrie Génétique, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U 955, IMRB, Psychiatrie Génétique, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A23">Université Paris Est, Faculté de Médecine, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Est, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A24">Fondation Fondamental, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Fondamental, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A25">AP-HP, Hôpital A. Chenevier - H. Mondor, Pôle de Psychiatrie, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital A. Chenevier - H. Mondor, Pôle de Psychiatrie, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Preisig, Martin" sort="Preisig, Martin" uniqKey="Preisig M" first="Martin" last="Preisig">Martin Preisig</name><affiliation wicri:level="1"><nlm:aff id="A29">Department of Psychiatry, Centre Hospitalier Universitaire Vaudois, Prilly, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Psychiatry, Centre Hospitalier Universitaire Vaudois, Prilly</wicri:regionArea><wicri:noRegion>Prilly</wicri:noRegion></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><affiliation wicri:level="3"><nlm:aff id="A30">Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A31">Swiss Institute of Bioinformatics, Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Bioinformatics, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Castelao, Enrique" sort="Castelao, Enrique" uniqKey="Castelao E" first="Enrique" last="Castelao">Enrique Castelao</name><affiliation wicri:level="1"><nlm:aff id="A29">Department of Psychiatry, Centre Hospitalier Universitaire Vaudois, Prilly, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Psychiatry, Centre Hospitalier Universitaire Vaudois, Prilly</wicri:regionArea><wicri:noRegion>Prilly</wicri:noRegion></affiliation></author><author><name sortKey="Wright, Adam" sort="Wright, Adam" uniqKey="Wright A" first="Adam" last="Wright">Adam Wright</name><affiliation wicri:level="1"><nlm:aff id="A32">School of Psychiatry, University of New South Wales, Randwick, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Psychiatry, University of New South Wales, Randwick</wicri:regionArea><wicri:noRegion>Randwick</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A33">Black Dog Institute, Prince of Wales Hospital, Randwick, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Black Dog Institute, Prince of Wales Hospital, Randwick</wicri:regionArea><wicri:noRegion>Randwick</wicri:noRegion></affiliation></author><author><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B." last="Mitchell">Philip B. Mitchell</name><affiliation wicri:level="1"><nlm:aff id="A32">School of Psychiatry, University of New South Wales, Randwick, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Psychiatry, University of New South Wales, Randwick</wicri:regionArea><wicri:noRegion>Randwick</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A33">Black Dog Institute, Prince of Wales Hospital, Randwick, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Black Dog Institute, Prince of Wales Hospital, Randwick</wicri:regionArea><wicri:noRegion>Randwick</wicri:noRegion></affiliation></author><author><name sortKey="Fullerton, Janice M" sort="Fullerton, Janice M" uniqKey="Fullerton J" first="Janice M." last="Fullerton">Janice M. Fullerton</name><affiliation wicri:level="3"><nlm:aff id="A34">Neuroscience Research Australia, Randwick, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Neuroscience Research Australia, Randwick, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A35">School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R." last="Schofield">Peter R. Schofield</name><affiliation wicri:level="3"><nlm:aff id="A34">Neuroscience Research Australia, Randwick, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Neuroscience Research Australia, Randwick, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A35">School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><nlm:aff id="A36">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name><affiliation wicri:level="1"><nlm:aff id="A36">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Gordon, Scott D" sort="Gordon, Scott D" uniqKey="Gordon S" first="Scott D." last="Gordon">Scott D. Gordon</name><affiliation wicri:level="1"><nlm:aff id="A36">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:aff id="A36">Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name><affiliation wicri:level="3"><nlm:aff id="A15">Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Liu, Chunyu" sort="Liu, Chunyu" uniqKey="Liu C" first="Chunyu" last="Liu">Chunyu Liu</name><affiliation wicri:level="4"><nlm:aff id="A37">Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de l'Illinois à Chicago</orgName></affiliation></author><author><name sortKey="Kleinman, Joel E" sort="Kleinman, Joel E" uniqKey="Kleinman J" first="Joel E." last="Kleinman">Joel E. Kleinman</name><affiliation wicri:level="2"><nlm:aff id="A2">Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hyde, Thomas M" sort="Hyde, Thomas M" uniqKey="Hyde T" first="Thomas M." last="Hyde">Thomas M. Hyde</name><affiliation wicri:level="2"><nlm:aff id="A2">Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Weinberger, Daniel R" sort="Weinberger, Daniel R" uniqKey="Weinberger D" first="Daniel R." last="Weinberger">Daniel R. Weinberger</name><affiliation wicri:level="2"><nlm:aff id="A2">Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, Maryland, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Su, Bing" sort="Su, Bing" uniqKey="Su B" first="Bing" last="Su">Bing Su</name><affiliation wicri:level="1"><nlm:aff id="A1">State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author></analytic><series><title level="j">The British journal of psychiatry : the journal of mental science</title><idno type="ISSN">0007-1250</idno><idno type="eISSN">1472-1465</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Summary</title><p id="P1">Bipolar disorder (BPD) is a highly heritable polygenic disorder. Recent enrichment analyses suggest that there may be true risk variants for BPD among the expression quantitative trait loci (eQTL) in the brain.</p></sec><sec id="S2"><title>Aims</title><p id="P2">We sought to assess the impact of eQTL variants on BPD risk by combining data from both BPD genome-wide association study (GWAS) and brain eQTL.</p></sec><sec id="S3"><title>Method</title><p id="P3">To detect single-nucleotide polymorphisms (SNPs) that influence expression levels of genes associated with BPD, we jointly analyzed data from a BPD GWAS (7,481 cases and 9,250 controls) and a genome-wide brain (cortical) eQTL (193 healthy controls) using a Bayesian statistical method, with independent follow-up replications. The identified risk SNP was then further tested for association with hippocampal volume (N=5,775) and cognitive performance (N=342) among healthy subjects.</p></sec><sec id="S4"><title>Results</title><p id="P4">Integrative analysis revealed a significant association between a brain eQTL rs6088662 in 20q11.22 and BPD (Log Bayes Factor=5.48; BPD p-val=5.85×10<sup>−5</sup>). Follow-up studies across multiple independent samples confirmed the association of the risk SNP (rs6088662) with gene expression and BPD susceptibility (p-val=3.54×10<sup>−8</sup>). Further exploratory analysis revealed that rs6088662 is also associated with hippocampal volume and cognitive performance in healthy subjects.</p></sec><sec id="S5"><title>Conclusions</title><p id="P5">Our findings suggest that 20q11.22 is likely a risk region for BPD, highlighting the informativeness of integrating functional annotation of genetic variants for gene expression in advancing our understanding of the biological basis underlying complex diseases such as BPD.</p></sec></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Danemark</li><li>France</li><li>Roumanie</li><li>République populaire de Chine</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>Basse-Saxe</li><li>Californie</li><li>Canton de Vaud</li><li>District de Cologne</li><li>District de Karlsruhe</li><li>Grand Est</li><li>Illinois</li><li>Lorraine (région)</li><li>Maryland</li><li>Massachusetts</li><li>Nouvelle-Galles du Sud</li><li>Rhénanie-du-Nord-Westphalie</li><li>Svealand</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Bonn</li><li>Chicago</li><li>Créteil</li><li>Göttingen</li><li>Lausanne</li><li>Mannheim</li><li>Paris</li><li>Pékin</li><li>Stockholm</li><li>Sydney</li><li>Toul</li></settlement><orgName><li>Université de l'Illinois à Chicago</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Li, Ming" sort="Li, Ming" uniqKey="Li M" first="Ming" last="Li">Ming Li</name></noRegion><name sortKey="Chen, Chunhui" sort="Chen, Chunhui" uniqKey="Chen C" first="Chunhui" last="Chen">Chunhui Chen</name><name sortKey="Chen, Chunhui" sort="Chen, Chunhui" uniqKey="Chen C" first="Chunhui" last="Chen">Chunhui Chen</name><name sortKey="Dong, Qi" sort="Dong, Qi" uniqKey="Dong Q" first="Qi" last="Dong">Qi Dong</name><name sortKey="Dong, Qi" sort="Dong, Qi" uniqKey="Dong Q" first="Qi" last="Dong">Qi Dong</name><name sortKey="Li, Xiao" sort="Li, Xiao" uniqKey="Li X" first="Xiao" last="Li">Xiao Li</name><name sortKey="Li, Xiao" sort="Li, Xiao" uniqKey="Li X" first="Xiao" last="Li">Xiao Li</name><name sortKey="Liu, Jiewei" sort="Liu, Jiewei" uniqKey="Liu J" first="Jiewei" last="Liu">Jiewei Liu</name><name sortKey="Liu, Jiewei" sort="Liu, Jiewei" uniqKey="Liu J" first="Jiewei" last="Liu">Jiewei Liu</name><name sortKey="Luo, Xiong Jian" sort="Luo, Xiong Jian" uniqKey="Luo X" first="Xiong-Jian" last="Luo">Xiong-Jian Luo</name><name sortKey="Su, Bing" sort="Su, Bing" uniqKey="Su B" first="Bing" last="Su">Bing Su</name><name sortKey="Yao, Yong Gang" sort="Yao, Yong Gang" uniqKey="Yao Y" first="Yong-Gang" last="Yao">Yong-Gang Yao</name><name sortKey="Zhang, Chen" sort="Zhang, Chen" uniqKey="Zhang C" first="Chen" last="Zhang">Chen Zhang</name><name sortKey="Zhang, Wen" sort="Zhang, Wen" uniqKey="Zhang W" first="Wen" last="Zhang">Wen Zhang</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Li, Ming" sort="Li, Ming" uniqKey="Li M" first="Ming" last="Li">Ming Li</name></region><name sortKey="Bergen, Sarah E" sort="Bergen, Sarah E" uniqKey="Bergen S" first="Sarah E." last="Bergen">Sarah E. Bergen</name><name sortKey="Chen, Chuansheng" sort="Chen, Chuansheng" uniqKey="Chen C" first="Chuansheng" last="Chen">Chuansheng Chen</name><name sortKey="Fuller, Chris K" sort="Fuller, Chris K" uniqKey="Fuller C" first="Chris K." last="Fuller">Chris K. Fuller</name><name sortKey="Hyde, Thomas M" sort="Hyde, Thomas M" uniqKey="Hyde T" first="Thomas M." last="Hyde">Thomas M. Hyde</name><name sortKey="Kleinman, Joel E" sort="Kleinman, Joel E" uniqKey="Kleinman J" first="Joel E." last="Kleinman">Joel E. Kleinman</name><name sortKey="Li, Hao" sort="Li, Hao" uniqKey="Li H" first="Hao" last="Li">Hao Li</name><name sortKey="Liu, Chunyu" sort="Liu, Chunyu" uniqKey="Liu C" first="Chunyu" last="Liu">Chunyu Liu</name><name sortKey="Luo, Xiong Jian" sort="Luo, Xiong Jian" uniqKey="Luo X" first="Xiong-Jian" last="Luo">Xiong-Jian Luo</name><name sortKey="Weinberger, Daniel R" sort="Weinberger, Daniel R" uniqKey="Weinberger D" first="Daniel R." last="Weinberger">Daniel R. Weinberger</name></country><country name="Suède"><region name="Svealand"><name sortKey="Landen, Mikael" sort="Landen, Mikael" uniqKey="Landen M" first="Mikael" last="Landén">Mikael Landén</name></region><name sortKey="Bergen, Sarah E" sort="Bergen, Sarah E" uniqKey="Bergen S" first="Sarah E." last="Bergen">Sarah E. Bergen</name><name sortKey="Hultman, Christina M" sort="Hultman, Christina M" uniqKey="Hultman C" first="Christina M." last="Hultman">Christina M. Hultman</name><name sortKey="Landen, Mikael" sort="Landen, Mikael" uniqKey="Landen M" first="Mikael" last="Landén">Mikael Landén</name></country><country name="Danemark"><noRegion><name sortKey="Mattheisen, Manuel" sort="Mattheisen, Manuel" uniqKey="Mattheisen M" first="Manuel" last="Mattheisen">Manuel Mattheisen</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name></noRegion><name sortKey="Castelao, Enrique" sort="Castelao, Enrique" uniqKey="Castelao E" first="Enrique" last="Castelao">Enrique Castelao</name><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltán" last="Kutalik">Zoltán Kutalik</name><name sortKey="Preisig, Martin" sort="Preisig, Martin" uniqKey="Preisig M" first="Martin" last="Preisig">Martin Preisig</name></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name></region><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name><name sortKey="Degenhardt, Franziska A" sort="Degenhardt, Franziska A" uniqKey="Degenhardt F" first="Franziska A." last="Degenhardt">Franziska A. Degenhardt</name><name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name><name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name><name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name><name sortKey="Schulze, Thomas G" sort="Schulze, Thomas G" uniqKey="Schulze T" first="Thomas G." last="Schulze">Thomas G. Schulze</name><name sortKey="Schulze, Thomas G" sort="Schulze, Thomas G" uniqKey="Schulze T" first="Thomas G." last="Schulze">Thomas G. 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Fullerton</name><name sortKey="Fullerton, Janice M" sort="Fullerton, Janice M" uniqKey="Fullerton J" first="Janice M." last="Fullerton">Janice M. Fullerton</name><name sortKey="Gordon, Scott D" sort="Gordon, Scott D" uniqKey="Gordon S" first="Scott D." last="Gordon">Scott D. Gordon</name><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B." last="Mitchell">Philip B. Mitchell</name><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B." last="Mitchell">Philip B. Mitchell</name><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R." last="Schofield">Peter R. Schofield</name><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R." last="Schofield">Peter R. Schofield</name><name sortKey="Wright, Adam" sort="Wright, Adam" uniqKey="Wright A" first="Adam" last="Wright">Adam Wright</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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